MRCGP AKT Question Bank
4,376 MRCGP Applied Knowledge Test questions across clinical medicine, evidence and admin. Try 100 free.
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About the MRCGP AKT exam
The MRCGP Applied Knowledge Test assesses the knowledge base underpinning UK general practice. MedPrep covers all three domains (clinical medicine, evidence-based practice, and health informatics/administration) with UK-guideline-referenced explanations tuned to the way the AKT tests real GP decision-making.
Who it's for
GP trainees (ST1 to ST3) preparing for the MRCGP Applied Knowledge Test.
Exam format
Around 200 items in 3h10m: single-best-answer, EMQs and data interpretation, delivered at a Pearson VUE centre.
Topics covered
Free sample MRCGP AKT questions
Try a few real questions from the bank. Pick an answer to check yourself and see the full explanation.
A 58-year-old man presents with low back pain 2 weeks post-lifting. X-ray lumbar spine: L1 vertebral compression fracture (fragility fracture - minimal trauma). History: long-term prednisolone 10 mg daily 5 years (rheumatoid arthritis), smoker 20 pack-years, alcohol 30 units/week, BMI 19 kg/m² (underweight). Investigations: calcium 2.35 mmol/L (normal 2.20-2.60 mmol/L), phosphate 1.1 mmol/L (normal 0.8-1.5 mmol/L), ALP 95 U/L (normal <120 U/L - excludes Paget's/osteomalacia), 25-OH vitamin D 35 nmol/L (insufficient - normal >50 nmol/L), testosterone 8 nmol/L (low-normal 10-30 nmol/L - hypogonadism), TSH 2.5 mU/L (normal), PTH 45 pg/mL (normal 10-65 pg/mL). DEXA scan: lumbar spine T-score -3.2 (osteoporosis - T-score <-2.5), femoral neck T-score -2.8 (osteoporosis). Clinical diagnosis: osteoporosis secondary causes (glucocorticoid-induced osteoporosis - prednisolone 10 mg daily 5 years, fragility fracture L1, male hypogonadism, underweight BMI 19, smoking, excess alcohol). What is the most appropriate management?
Select an answer to see the explanation.
A 68-year-old woman on theophylline 200 mg BD (COPD) starts clarithromycin 500 mg BD for pneumonia. Three days later develops nausea, vomiting, tremor, palpitations. ECG: multifocal atrial tachycardia. Theophylline level 35 mg/L (therapeutic 10-20 mg/L). Diagnosis: theophylline toxicity precipitated by clarithromycin CYP1A2 inhibition. Which principle underlies theophylline narrow therapeutic index toxicity?
Select an answer to see the explanation.
A 45-year-old woman presents with 18 months chronic widespread pain (neck + shoulders + back + hips + thighs bilateral, constant aching, worse morning stiffness >30 min). History: fatigue severe (limits daily activities), poor sleep (non-restorative - wakes unrefreshed), headaches, irritable bowel symptoms. Examination: multiple tender points (11/18 specific sites - occiput/low cervical/trapezius/supraspinatus/2nd rib/lateral epicondyle/gluteal/greater trochanter/knee, pain pressure 4 kg/cm², no joint swelling/effusion). Investigations: FBC normal, ESR 12 mm/hr (normal), CRP <5 mg/L (normal), TSH 2.5 mU/L (normal - excludes hypothyroidism), vitamin D 65 nmol/L (normal >50 nmol/L), rheumatoid factor negative, ANA negative, anti-CCP negative, CK 85 U/L (normal - excludes myositis). X-ray hands/feet: no erosions (excludes inflammatory arthritis). Clinical diagnosis: fibromyalgia (chronic widespread pain >3 months + multiple tender points 11/18 + fatigue + sleep disturbance + normal investigations exclude inflammatory/structural disease, central pain sensitization syndrome). What is the most appropriate management?
Select an answer to see the explanation.
MRCGP AKT revision notes
Free clinician-written notes for topics tested in MRCGP AKT.
Frequently asked questions
Is MedPrep's MRCGP AKT question bank free?
You can answer 100 MRCGP AKT questions completely free, with full explanations and progress tracking, and no card is required. After that, a single affordable subscription unlocks the whole bank.
How many MRCGP AKT questions are there?
The MRCGP AKT bank has 4,376 exam-style questions, each with a structured, guideline-referenced explanation.
Are the questions up to date with UK guidelines?
Yes. Every explanation is cross-referenced against current NICE, BNF and relevant UK/European guidelines, and the bank is curated by a UK-trained, CCT-holding clinician.