MRCGP AKT Question Bank
4,376 MRCGP Applied Knowledge Test questions across clinical medicine, evidence and admin. Try 100 free.
“You have such a good site.” — Lydia, MRCP Part 2 subscriber
About the MRCGP AKT exam
The MRCGP Applied Knowledge Test assesses the knowledge base underpinning UK general practice. MedPrep covers all three domains (clinical medicine, evidence-based practice, and health informatics/administration) with UK-guideline-referenced explanations tuned to the way the AKT tests real GP decision-making.
Who it's for
GP trainees (ST1 to ST3) preparing for the MRCGP Applied Knowledge Test.
Exam format
Around 200 items in 3h10m: single-best-answer, EMQs and data interpretation, delivered at a Pearson VUE centre.
Topics covered
Free sample MRCGP AKT questions
Try a few real questions from the bank. Pick an answer to check yourself and see the full explanation.
A 68-year-old man with atrial fibrillation is stable on warfarin 5mg daily with INR consistently 2.5-3.0. He develops a chest infection and his GP prescribes a 7-day course of clarithromycin 500mg twice daily. Four days later, he presents with spontaneous bruising and haematuria. INR is 7.8. He has taken no additional medications or alcohol, and dietary vitamin K intake is unchanged.
Which mechanism best explains this drug interaction?
Select an answer to see the explanation.
A 32-year-old woman presents with 6 months fatigue, arthralgia hands + knees (non-erosive), malar rash cheeks (spares nasolabial folds - butterfly distribution, worsens sun exposure photosensitivity). History: 2 miscarriages (12 weeks + 16 weeks), deep vein thrombosis left leg 1 year ago. Examination: malar rash erythematous raised, no discoid lesions. Hands: synovitis MCP/PIP joints bilaterally, no deformities. Investigations: ANA positive 1:640 (homogeneous pattern - highly sensitive 95-100% SLE), anti-dsDNA positive high titre (specific 95% SLE - correlates disease activity nephritis risk), anti-Smith antibody positive (highly specific 99% SLE - 30% prevalence), complement C3 0.6 g/L (low - normal 0.9-1.8 g/L), C4 0.08 g/L (low - normal 0.1-0.4 g/L). Rheumatoid factor negative, anti-CCP negative. FBC: Hb 105 g/L (anemia), WCC 3.2 × 10⁹/L (leukopenia), lymphocytes 0.8 × 10⁹/L (lymphopenia <1.0), platelets 95 × 10⁹/L (thrombocytopenia). Urinalysis: protein 2+ (proteinuria - lupus nephritis screen). Clinical diagnosis: systemic lupus erythematosus SLE (malar rash + photosensitivity + arthritis + cytopenias + ANA positive + anti-dsDNA positive + low complement, multisystem autoimmune connective tissue disease). What is the most appropriate management?
Select an answer to see the explanation.
A 65-year-old woman on simvastatin 80 mg OD starts clarithromycin 500 mg BD for pneumonia. Five days later develops severe muscle pain (thighs, calves), weakness, dark urine. Investigations: CK 15,000 U/L (normal <200), Cr 180 µmol/L (baseline 90), myoglobinuria positive. Diagnosis: simvastatin-induced rhabdomyolysis precipitated by clarithromycin. Which mechanism underlies statin-CYP3A4 inhibitor interaction toxicity?
Select an answer to see the explanation.
MRCGP AKT revision notes
Free clinician-written notes for topics tested in MRCGP AKT.
Frequently asked questions
Is MedPrep's MRCGP AKT question bank free?
You can answer 100 MRCGP AKT questions completely free, with full explanations and progress tracking, and no card is required. After that, a single affordable subscription unlocks the whole bank.
How many MRCGP AKT questions are there?
The MRCGP AKT bank has 4,376 exam-style questions, each with a structured, guideline-referenced explanation.
Are the questions up to date with UK guidelines?
Yes. Every explanation is cross-referenced against current NICE, BNF and relevant UK/European guidelines, and the bank is curated by a UK-trained, CCT-holding clinician.